Srikumar Sahasranaman Selected Research

GDC-0425

5/2017	Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors.
12/2016	A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma.

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Srikumar Sahasranaman Research Topics

Disease

15	Neoplasms (Cancer) 01/2024 - 08/2008
5	Breast Neoplasms (Breast Cancer) 12/2021 - 11/2018
3	Body Weight (Weight, Body) 01/2023 - 09/2005
2	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 11/2021 - 01/2021
2	Asthma (Bronchial Asthma) 10/2006 - 09/2005
1	Hodgkin Disease (Hodgkin's Disease) 01/2024
1	Dyspnea (Shortness of Breath) 05/2017
1	Nausea 05/2017
1	Thrombocytopenia (Thrombopenia) 05/2017
1	Fever (Fevers) 05/2017
1	Neutropenia 05/2017
1	Syncope (Fainting) 05/2017
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2015
1	Disease Progression 01/2015
1	Dyskinesias (Dyskinesia) 05/2011
1	Parkinson Disease (Parkinson's Disease) 05/2011
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/2008
1	Rheumatic Diseases (Rheumatism) 08/2008

Drug/Important Bio-Agent (IBA)

6	zanubrutinibIBA 01/2023 - 01/2020
4	3- (4- (2- (2- chloro- 4- fluorophenyl)- 1- (1H- indazol- 5- yl)but- 1- en- 1- yl)phenyl)acrylic acidIBA 01/2019 - 10/2018
4	Estrogen ReceptorsIBA 01/2019 - 10/2018
2	tislelizumabIBA 01/2024 - 01/2023
2	Cytochrome P-450 CYP3A InhibitorsIBA 01/2023 - 01/2021
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 12/2021 - 01/2021
2	Peptides (Polypeptides)IBA 12/2021 - 11/2018
2	AnionsIBA 12/2021 - 11/2018
2	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2021
2	Immune Checkpoint InhibitorsIBA 09/2021 - 02/2016
2	Rifampin (Rifampicin)FDA LinkGeneric 01/2021 - 01/2021
2	Cytochrome P-450 CYP3AIBA 01/2021 - 01/2021
2	Midazolam (Versed)FDA LinkGeneric 01/2021 - 01/2021
2	Itraconazole (Sporanox)FDA LinkGeneric 01/2021 - 01/2021
2	pamiparibIBA 01/2021 - 01/2021
2	Agammaglobulinaemia Tyrosine KinaseIBA 01/2021 - 01/2020
2	Alanine Transaminase (SGPT)IBA 01/2021 - 05/2017
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2021 - 01/2021
2	GDC-0425IBA 05/2017 - 12/2016
2	Therapeutic UsesIBA 02/2016 - 05/2011
2	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2006 - 09/2005
1	Monoclonal AntibodiesIBA 01/2024
1	Programmed Cell Death 1 ReceptorIBA 01/2024
1	AntibodiesIBA 01/2023
1	AlbuminsIBA 01/2023
1	CationsIBA 12/2021
1	Organic Anion TransportersIBA 12/2021
1	Cytochrome P-450 CYP2C19IBA 01/2021
1	methylamphotericin B (AME)IBA 01/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2021
1	Rosuvastatin Calcium (Crestor)FDA Link 01/2021
1	AcidsIBA 01/2021
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2021
1	BilirubinIBA 01/2021
1	CreatinineIBA 01/2021
1	Digoxin (Digitek)FDA LinkGeneric 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	Omeprazole (Prilosec)FDA LinkGeneric 01/2021
1	Warfarin (Coumadin)FDA LinkGeneric 01/2021
1	Reducing AgentsIBA 01/2021
1	Proton Pump InhibitorsIBA 01/2021
1	Cytochrome P-450 CYP2C9IBA 01/2021
1	cyclopropapyrroloindoleIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 05/2017
1	Gemcitabine FDA Link 05/2017
1	Checkpoint Kinase 1IBA 05/2017
1	Rituximab (Mabthera)FDA Link 01/2015
1	navitoclaxIBA 01/2015
1	mavoglurantIBA 05/2011
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 05/2011
1	Levodopa (L Dopa)FDA LinkGeneric 05/2011
1	acivicin (AT 125)IBA 05/2011
1	Thioguanine (Tioguanine)FDA Link 08/2008
1	2-mercaptopurineIBA 08/2008
1	Azathioprine (Imuran)FDA LinkGeneric 08/2008
1	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 08/2008
1	Mometasone Furoate (Nasonex)FDA LinkGeneric 10/2006
1	Fluticasone (Cutivate)FDA LinkGeneric 10/2006
1	Budesonide (Pulmicort)FDA LinkGeneric 10/2006
1	Beclomethasone (Beclometasone)FDA Link 10/2006
1	desisobutyrylciclesonideIBA 09/2005
1	ciclesonide FDA Link 09/2005

Therapy/Procedure

2	Immunotherapy 09/2021 - 02/2016
1	Therapeutics 02/2016